Exact solutions for supersymmetric stationary black hole composites

Four dimensional N=2 supergravity has regular, stationary, asymptotically flat BPS solutions with intrinsic angular momentum, describing bound states of separate extremal black holes with mutually nonlocal charges. Though the existence and some properties of these solutions were established some time ago, fully explicit analytic solutions were lacking thus far. In this note, we fill this gap. We show in general that explicit solutions can be constructed whenever an explicit formula is known in the theory at hand for the Bekenstein-Hawking entropy of a single black hole as a function of its charges, and illustrate this with some simple examples. We also give an example of moduli-dependent black hole entropy.Comment: 13 pages, 1 figur

Social-ecological trends: managing the vulnerability of coastal fishing communities

The loss of biodiversity, including the collapse of fish stocks, affects the vulnerability of social-ecological systems (SESs) and threatens local livelihoods. Incorporating community-centered indicators and SES drivers and exposures of change into coastal management can help anticipate and mitigate human and/or coastal vulnerability. We have proposed a new index to measure the social-ecological vulnerability of coastal fishing communities (Index of Coastal Vulnerability [ICV]) based on species, ecosystem, and social indicators. The ICV varies from 0 (no vulnerability) to 1 (very high vulnerability) and is composed of 3 components: species vulnerability, i.e., fish biological traits; ecosystem vulnerability, i.e., environmental indicators of ecosystem health; and adaptive capacity, i.e., human ability to cope with changes. We tested the ICV of Brazil’s 17 coastal states. The average ICV for the Brazilian coast was 0.77, and variation was low among states. More than half of the coastal states revealed very high vulnerability (> 0.8). The ecosystem vulnerability values were worse than the adaptive capacity and species vulnerability values, and the North and Northeast regions were revealed to be vulnerable hot spots. Additionally, we investigated how the ICV related to specific anthropogenic risks, i.e., fish landing richness, fishery instability, market, coastal extension, and coastal population, and found that states with fewer species landings and higher coastal populations presented higher ICVs. At a time when human impacts are overtaking natural processes, understanding how these impacts lead to coastal vulnerability can help improve conservation policies. For this case study, we suggest both fisheries management measures and restoration of sensitive habitats to protect species and decrease vulnerability. The integrated evaluation developed here could be used as a baseline for coastal monitoring and conservation planning and be applied to coastal regions in which governments evaluate both social and biological aspects.Postprint2,51

A social-ecological approach to estimate fisher resilience: a case study from Brazil

Social-ecological systems (SESs), such as fishing communities, are human and biophysical subsystems that are intrinsically connected to one another and strongly depend on natural resources. That is why these human groups are usually the first to feel the effects of policies concerning fisheries and ocean governance and the most affected by them. These policies can potentially build or erode social-ecological resilience (SER), especially if they are coupled with environmental changes. SER assessments offer a valuable tool to identify human-nature linkages, and the implications and feedbacks in SESs when facing human-induced or natural changes. We created a SER index by combining interviews with fishers with environmental datasets on a fine scale that has never been presented for the Brazilian coast. This scale was then tested in marine protected areas that allow sustainable use. Our approach estimated SER from information on fisheries ecosystem services and adaptive capacity at the local scale, considering the individual and community levels. We synthesized blocks of critical indicators of an individual or community’s ability to build and maintain resilience in SESs, such as flexibility, ability to learn, ability to organize, assets, social capital, and ecological characteristics. We identified that fishers’ ability to learn and to organize, as well as the biological sensitivity of an ecosystem are determinant to enhancing SER in the studied coastal communities. A Bayesian model also showed that the fishers’ SER was related to socioeconomic factors, thereby indicating that older fishers, fishers who consistently catch more fish, and fishers with a higher reliance on fishing for their income presented lower index values. By knowing the variables that influence the ability of fishers to cope with changes to their SESs, we can devise smarter management approaches that may include compensatory mechanisms for more fragile fishers. Our findings can also inform decision making about where fisheries management strategies are likely to be more participative and effective in order to minimize the social impacts of policy decisions and increase SER in coastal communities.Postprint2,51

Cranial Masses in Sickle Cell Disease

info:eu-repo/semantics/publishedVersio

GASTRIC CARCINOMA WITH OSSEOUS METAPLASIA IN A DOG

This report describes an unprecedented case of a gastric carcinoma with osseous metaplasia in a 8-year-old male standard poodle. An exploratory laparotomy revealed a firm yellowish nodular mass in the pyloric region. The lesion was surgically removed and submitted for current histological examination. Immunohistochemistry was performed employing monoclonal antibodies for pan-cytokeratin, vimentin, smooth muscular a-actin and BMP-2/4. The mass consisted in neoplastic proliferation of epithelial cells, arranged in a tubular or acinar pattern and supported by scirrhous stroma, with mucin production and multiple foci of heterotopic ossification. Neoplastic epithelial cells showed strong positive immunostaining for AE1/AE3 and BMP-2/4, although they were negative for both vimentin and a-actin. Histopathological findings suggested that the bone tissue may be primarily originated from neoplastic epithelial cells which directly circumscribe the osseous metaplasia foci

Moduli Stabilisation in Heterotic Models with Standard Embedding

In this note we analyse the issue of moduli stabilisation in 4d models obtained from heterotic string compactifications on manifolds with SU(3) structure with standard embedding. In order to deal with tractable models we first integrate out the massive fields. We argue that one can not only integrate out the moduli fields, but along the way one has to truncate also the corresponding matter fields. We show that the effective models obtained in this way do not have satisfactory solutions. We also look for stabilised vacua which take into account the presence of the matter fields. We argue that this also fails due to a no-go theorem for Minkowski vacua in the moduli sector which we prove in the end. The main ingredient for this no-go theorem is the constraint on the fluxes which comes from the Bianchi identity.Comment: 20 pages, LaTeX; references adde

Efeitos antiangiogênicos in vivo convalidam a atividade antineoplásica potencial do metiljasmonato

Molecular plant components have long been aimed at the angiogenesis and anti-angiogenesis pathways, and have been tested as sources for antineoplasic drugs with promising success. The present work deals with the anti-angiogenic effects of Methyl Jasmonate. Jasmonate derivatives were demonstrated to selectively damage the mitochondria of cancer cells. In vitro, 1-10 mM Methyl Jasmonate induced the cell death of the human umbilical vein endothelial cells (HUVEC) and the Murine melanoma cells (B16F10), while micromolar concentrations were ineffective. In vivo, comparable concentrations were toxic and reduced the vessel density of the Chorioallantoic Membrane of the Chicken Embryo (CAM). However, 1-10 µM concentrations produced a complex effect. There was increased capillary budding, but the new vessels were leakier and less organised than corresponding controls. It is suggested that not only direct toxicity, but also the drug effects upon angiogenesis are relevant to the antineoplasic effects of Methyl Jasmonate.Moléculas de origem vegetal são, há muito, conhecidas como substâncias ativas sobre as vias de angiogênese e antiangiogênese e foram testadas como fonte de drogas antineoplásicas com sucesso promissor. Este trabalho trata dos efeitos antiangiogênicos do Metiljasmonato, um protótipo da família dos derivados do ácido jasmônico, que danificam seletivamente a mitocôndria de células neoplásicas. In vitro, metiljasmonato 1-10 mM promoveu a morte celular de células endoteliais humanas de cordão umbilical (HUVEC) e de melanoma murino (B16F10); concentrações micromolares foram inócuas. In vivo, concentrações equivalentes foram tóxicas e reduziram a densidade de vasos em membranas corioalantoicas de embrião de galinha (CAM). Entretanto, concentrações entre 1-10 µM produziram um efeito complexo. Ocorreu aumento no brotamento capilar, mas os novos vasos apresentaram-se frágeis e menos organizados que os controles correspondentes. Sugere-se que, além da toxicidade direta contra as células tumorais, a ação do metiljasmonato sobre a angiogênese seja relevante para seu efeito antineoplásico

Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion

Background: The ability of stroke volume variation (SVV), pulse pressure variation (PPV) and global end-diastolic volume (GEDV) for prediction of fluid responsiveness in presence of pleural effusion is unknown. The aim of the present study was to challenge the ability of SVV, PPV and GEDV to predict fluid responsiveness in a porcine model with pleural effusions. Methods: Pigs were studied at baseline and after fluid loading with 8 ml kg−1 6% hydroxyethyl starch. After withdrawal of 8 ml kg−1 blood and induction of pleural effusion up to 50 ml kg−1 on either side, measurements at baseline and after fluid loading were repeated. Cardiac output, stroke volume, central venous pressure (CVP) and pulmonary occlusion pressure (PAOP) were obtained by pulmonary thermodilution, whereas GEDV was determined by transpulmonary thermodilution. SVV and PPV were monitored continuously by pulse contour analysis. Results: Pleural effusion was associated with significant changes in lung compliance, peak airway pressure and stroke volume in both responders and non-responders. At baseline, SVV, PPV and GEDV reliably predicted fluid responsiveness (area under the curve 0.85 (p<0.001), 0.88 (p<0.001), 0.77 (p = 0.007). After induction of pleural effusion the ability of SVV, PPV and GEDV to predict fluid responsiveness was well preserved and also PAOP was predictive. Threshold values for SVV and PPV increased in presence of pleural effusion. Conclusions: In this porcine model, bilateral pleural effusion did not affect the ability of SVV, PPV and GEDV to predict fluid responsiveness

DWSB in heterotic flux compactifications

We address the construction of non-supersymmetric vacua in heterotic compactifications with intrinsic torsion and background fluxes. In particular, we implement the approach of domain-wall supersymmetry breaking (DWSB) previously developed in the context of type II flux compactifications. This approach is based on considering backgrounds where probe NS5-branes wrapping internal three-cycles and showing up as four-dimensional domain-walls do not develop a BPS bound, while all the other BPS bounds characterizing the N=1 supersymmetric compactifications are preserved at tree-level. Via a scalar potential analysis we provide the conditions for these backgrounds to solve the ten-dimensional equations of motion including order \alpha' corrections. We also consider backgrounds where some of the NS5-domain-walls develop a BPS bound, show their relation to no-scale SUSY-breaking vacua and construct explicit examples via elliptic fibrations. Finally, we consider backgrounds with a non-trivial gaugino condensate and discuss their relation to supersymmetric and non-supersymmetric vacua in the present context.Comment: 56 pages, 1 figur

Five-Brane Superpotentials, Blow-Up Geometries and SU(3) Structure Manifolds

We investigate the dynamics of space-time filling five-branes wrapped on curves in heterotic and orientifold Calabi-Yau compactifications. We first study the leading N=1 scalar potential on the infinite deformation space of the brane-curve around a supersymmetric configuration. The higher order potential is also determined by a brane superpotential which we compute for a subset of light deformations. We argue that these deformations map to new complex structure deformations of a non-Calabi-Yau manifold which is obtained by blowing up the brane-curve into a four-cycle and by replacing the brane by background fluxes. This translates the original brane-bulk system into a unifying geometrical formulation. Using this blow-up geometry we compute the complete set of open-closed Picard-Fuchs differential equations and identify the brane superpotential at special points in the field space for five-branes in toric Calabi-Yau hypersurfaces. This has an interpretation in open mirror symmetry and enables us to list compact disk instanton invariants. As a first step towards promoting the blow-up geometry to a supersymmetric heterotic background we propose a non-Kaehler SU(3) structure and an identification of the three-form flux.Comment: 95 pages, 4 figures; v2: Minor corrections, references update